{"id":5181,"date":"2022-08-02T18:33:11","date_gmt":"2022-08-02T10:33:11","guid":{"rendered":"http:\/\/139.9.1.231\/?p=5181"},"modified":"2022-08-21T15:02:20","modified_gmt":"2022-08-21T07:02:20","slug":"alphafold2-2","status":"publish","type":"post","link":"http:\/\/139.9.1.231\/index.php\/2022\/08\/02\/alphafold2-2\/","title":{"rendered":"AlphaFold2\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b"},"content":{"rendered":"\n<p>\u6458\u81ea&nbsp;<a href=\"javascript:void(0);\">\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u5de5\u7a0b\u5e08<\/a><\/p>\n\n\n\n<p>\u79d1\u5b66\u754c\u5df2\u77e5\u7684\u51e0\u4e4e\u6240\u6709\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u90fd\u5728\u8fd9\u91cc\u4e86\u3002\u86cb\u767d\u8d28\u662f\u751f\u547d\u7684\u57fa\u7840\u6784\u4ef6\uff0c\u5b83\u4eec\u7531\u6c28\u57fa\u9178\u94fe\u7ec4\u6210\uff0c\u6298\u53e0\u6210\u4e0d\u540c\u7684\u590d\u6742\u5f62\u72b6\u3002\u86cb\u767d\u8d28\u7684\u529f\u80fd\u901a\u5e38\u7531\u5176 3D \u7ed3\u6784\u51b3\u5b9a\u3002\u5982\u679c\u6211\u4eec\u4e86\u89e3\u86cb\u767d\u8d28\u7684\u6298\u53e0\u65b9\u5f0f\uff0c\u5c31\u53ef\u4ee5\u5f00\u59cb\u63a2\u7d22\u5b83\u4eec\u662f\u5982\u4f55\u5de5\u4f5c\u7684\uff0c\u5e76\u5c1d\u8bd5\u6539\u53d8\u5b83\u4eec\u7684\u529f\u80fd\u3002<strong>\u5c3d\u7ba1 DNA \u63d0\u4f9b\u4e86\u5236\u9020\u6c28\u57fa\u9178\u94fe\u7684\u6307\u4ee4\uff0c\u4f46\u9884\u6d4b\u5b83\u4eec\u5982\u4f55\u76f8\u4e92\u4f5c\u7528\u4ee5\u5f62\u6210\u86cb\u767d\u8d28\u7684 3D \u7ed3\u6784\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\u3002<\/strong><br>\u4e00\u5e74\u524d\uff0cDeepMind \u53d1\u5e03\u4e86 AlphaFold2\uff0c\u4ee5\u539f\u5b50\u6c34\u5e73\u7684\u51c6\u786e\u5ea6\u9884\u6d4b\u4e86 2\/3 \u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u5e76\u4e0e EMBL-EBI \u5171\u540c\u53d1\u5e03\u4e86\u5f00\u653e\u53ef\u641c\u7d22\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u5e93 AlphaFold DB\uff0c\u4e0e\u4e16\u754c\u5171\u540c\u5206\u4eab\u8fd9\u4e00\u6280\u672f\u3002<br>7 \u6708 28 \u65e5\uff0cDeepMind \u5ba3\u5e03\u00a0<strong>AlphaFold DB<\/strong>\u00a0\u5df2\u4ece 100 \u4e07\u4e2a\u7ed3\u6784\u6269\u5c55\u5230\u8d85\u8fc7 2 \u4ebf\u4e2a\u7ed3\u6784\uff0c\u6269\u5927\u8d85\u8fc7 200 \u500d\uff0c\u8fd9\u4e00\u8fdb\u5c55\u5c06\u6781\u5927\u5730\u63d0\u5347\u4eba\u4eec\u5bf9\u4e8e\u751f\u7269\u5b66\u7684\u7406\u89e3\u3002<br><strong>\u51e0\u4e4e\u6db5\u76d6\u6240\u6709\u5df2\u77e5\u86cb\u767d\u8d28<\/strong><br>\u300c\u4f60\u53ef\u4ee5\u8ba4\u4e3a\u5b83\u57fa\u672c\u6db5\u76d6\u4e86\u6240\u6709\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u5305\u62ec\u690d\u7269\u3001\u7ec6\u83cc\u3001\u52a8\u7269\u548c\u8bb8\u591a\u5176\u4ed6\u751f\u7269\u7684\u9884\u6d4b\u7ed3\u6784\uff0c\u8fd9\u4e3a AlphaFold \u5f00\u8f9f\u4e86\u5de8\u5927\u7684\u65b0\u673a\u4f1a\uff0c\u53ef\u4ee5\u5bf9\u73af\u4fdd\u3001\u7cae\u98df\u5b89\u5168\u548c\u88ab\u5ffd\u89c6\u75be\u75c5\u7b49\u91cd\u8981\u95ee\u9898\u4ea7\u751f\u5f71\u54cd\uff0c\u300dDeepMind \u521b\u59cb\u4eba\u3001\u9996\u5e2d\u6267\u884c\u5b98\u6770\u7c73\u65af \u00b7 \u54c8\u8428\u6bd4\u65af\u5728\u4ecb\u7ecd AlphaFold DB \u8fd9\u6b21\u6269\u5c55\u65f6\u8bf4\u9053\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" width=\"808\" height=\"594\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-20.png\" alt=\"\" class=\"wp-image-5184\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-20.png 808w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-20-300x221.png 300w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-20-768x565.png 768w\" sizes=\"(max-width: 808px) 100vw, 808px\" \/><\/figure>\n\n\n\n<p>\u8fd9\u4e00\u66f4\u65b0\u5305\u62ec\u690d\u7269\u3001\u7ec6\u83cc\u3001\u52a8\u7269\u548c\u5176\u4ed6\u751f\u7269\u7684\u86cb\u767d\u8d28\u9884\u6d4b\u7ed3\u6784\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" width=\"718\" height=\"519\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-21.png\" alt=\"\" class=\"wp-image-5185\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-21.png 718w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-21-300x217.png 300w\" sizes=\"(max-width: 718px) 100vw, 718px\" \/><\/figure>\n\n\n\n<p>      \u8fd9\u4e00\u66f4\u65b0\u610f\u5473\u7740\u86cb\u767d\u8d28\u6570\u636e\u5e93 UniProt \u90fd\u5c06\u5e26\u6709\u86cb\u767d\u8d28\u9884\u6d4b\u7ed3\u6784\uff08UniProt \u662f\u4e00\u4e2a\u5168\u9762\u7684\uff0c\u9ad8\u8d28\u91cf\u7684\uff0c\u514d\u8d39\u4f7f\u7528\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u4e0e\u529f\u80fd\u4fe1\u606f\u6570\u636e\u5e93\uff0c\u5b83\u8fd8\u5305\u542b\u4e86\u5927\u91cf\u6765\u81ea\u7814\u7a76\u6587\u732e\u7684\u5173\u4e8e\u86cb\u767d\u7684\u751f\u7269\u5b66\u529f\u80fd\u4fe1\u606f\uff09\u3002\u7814\u7a76\u8005\u53ef\u4ee5\u901a\u8fc7 Google Cloud Public Datasets \u6279\u91cf\u4e0b\u8f7d\uff0c\u8ba9\u4e16\u754c\u5404\u5730\u7684\u79d1\u5b66\u5bb6\u66f4\u5bb9\u6613\u8bbf\u95ee AlphaFold\u3002<br>\u65af\u514b\u91cc\u666e\u65af\u8f6c\u5316\u7814\u7a76\u6240\u521b\u59cb\u4eba Eric Topol \u8868\u793a\uff1a\u300cAlphaFold \u662f\u751f\u547d\u79d1\u5b66\u9886\u57df\u72ec\u4e00\u65e0\u4e8c\u7684\u91cd\u5927\u8fdb\u6b65\uff0c\u5c55\u793a\u4e86 AI \u7684\u529b\u91cf\u3002\u8fc7\u53bb\u786e\u5b9a\u86cb\u767d\u8d28\u7684 3D \u7ed3\u6784\u9700\u8981\u6570\u6708\u6216\u6570\u5e74\uff0c\u73b0\u5728\u53ea\u9700\u51e0\u79d2\u949f\u3002AlphaFold \u5df2\u7ecf\u52a0\u901f\u5e76\u5b9e\u73b0\u4e86\u5927\u89c4\u6a21\u53d1\u73b0\uff0c\u5305\u62ec\u7834\u89e3\u6838\u5b54\u590d\u5408\u4f53\u7684\u7ed3\u6784\u3002\u65b0\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u4e0d\u65ad\u589e\u52a0\uff0c\u51e0\u4e4e\u7167\u4eae\u4e86\u6574\u4e2a\u86cb\u767d\u8d28\u5b87\u5b99\uff0c\u6211\u4eec\u53ef\u4ee5\u671f\u5f85\u6bcf\u5929\u90fd\u6709\u66f4\u591a\u7684\u751f\u7269\u8c1c\u56e2\u88ab\u89e3\u5f00\u3002\u300d<br><strong>AlphaFold \u7684\u5f71\u54cd<\/strong><br>\u81ea\u53d1\u5e03\u81f3\u4eca\uff0cAlphaFold \u5df2\u4ea7\u751f\u4ee4\u4eba\u96be\u4ee5\u7f6e\u4fe1\u7684\u5f71\u54cd\u3002\u5b83\u662f DeepMind \u6784\u5efa\u7684\u6700\u590d\u6742\u7684\u4eba\u5de5\u667a\u80fd\u7cfb\u7edf\uff0c\u9700\u8981\u591a\u9879\u5173\u952e\u521b\u65b0\uff0c\u5e76\u5df2\u5e94\u7528\u5230\u591a\u79cd\u4e0b\u6e38\u4efb\u52a1\u4e2d\u3002<br>AlphaFold2 \u53ef\u4ee5\u5728\u539f\u5b50\u7cbe\u5ea6\u4e0a\u51c6\u786e\u5730\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u5b83\u4e0d\u4ec5\u4e3a\u751f\u7269\u5b66\u4e2d 50 \u5e74\u6765\u7684\u91cd\u5927\u6311\u6218\u63d0\u4f9b\u4e86\u89e3\u51b3\u65b9\u6848\uff0c\u4e5f\u8bc1\u660e\u4e86\uff1a\u4eba\u5de5\u667a\u80fd\u53ef\u4ee5\u6781\u5927\u5730\u52a0\u901f\u79d1\u5b66\u53d1\u73b0\uff0c\u8fdb\u800c\u63a8\u52a8\u4eba\u7c7b\u8fdb\u6b65\uff0c\u8fd9\u4e00\u70b9\u610f\u4e49\u91cd\u5927\u3002<br>DeepMind \u5df2\u7ecf\u5f00\u6e90\u4e86 AlphaFold \u7684\u4ee3\u7801\uff0c\u5e76\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e24\u7bc7\u6df1\u5ea6\u8bba\u6587\uff0c\u5f15\u7528\u91cf\u5df2\u8d85\u8fc7 4000\u3002\u6b64\u5916\uff0cDeepMind \u8fd8\u4e0e EMBL-EBI \u5408\u4f5c\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5e2e\u52a9\u751f\u7269\u5b66\u5bb6\u4f7f\u7528 AlphaFold \u7684\u5de5\u5177\uff0c\u5e76\u5171\u540c\u53d1\u5e03\u4e86 AlphaFold DB\u3002<br>\u5728\u53d1\u5e03 AlphaFold \u4e4b\u524d\uff0cDeepMind \u5f81\u6c42\u4e86 30 \u591a\u540d\u751f\u7269\u5b66\u7814\u7a76\u4e13\u5bb6\u7684\u610f\u89c1\uff0c\u4f7f\u5f97\u4ed6\u4eec\u4ee5\u6700\u5927\u5316\u6f5c\u5728\u5229\u76ca\u548c\u6700\u5c0f\u5316\u6f5c\u5728\u98ce\u9669\u7684\u65b9\u5f0f\u4e0e\u4e16\u754c\u5206\u4eab AlphaFold \u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" width=\"748\" height=\"786\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-22.png\" alt=\"\" class=\"wp-image-5187\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-22.png 748w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-22-285x300.png 285w\" sizes=\"(max-width: 748px) 100vw, 748px\" \/><\/figure>\n\n\n\n<p>\u8fc4\u4eca\u4e3a\u6b62\uff0c\u6765\u81ea 190 \u4e2a\u56fd\u5bb6 \/ \u5730\u533a\u7684\u8d85\u8fc7 500000 \u540d\u7814\u7a76\u4eba\u5458\u8bbf\u95ee\u4e86 AlphaFold DB\uff0c\u67e5\u770b\u4e86\u8d85\u8fc7 200 \u4e07\u4e2a\u7ed3\u6784\u3002\u4e00\u4e9b\u514d\u8d39\u63d0\u4f9b\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u4e5f\u5df2\u96c6\u6210\u5230\u5176\u4ed6\u516c\u5171\u6570\u636e\u96c6\u4e2d\uff0c\u4f8b\u5982 Ensembl\u3001UniProt \u548c OpenTargets\uff0c\u88ab\u6570\u767e\u4e07\u7528\u6237\u8bbf\u95ee\u3002<\/p>\n\n\n\n<p>\u5728\u4e0e\u5176\u4ed6\u673a\u6784\u5408\u4f5c\u65f6\uff0cDeepMind \u4f18\u5148\u8003\u8651\u90a3\u4e9b\u6700\u5177\u79ef\u6781\u793e\u4f1a\u6548\u76ca\u7684\u5e94\u7528\uff0c\u91cd\u70b9\u5173\u6ce8\u90a3\u4e9b\u8d44\u91d1\u4e0d\u8db3\u6216\u88ab\u5ffd\u89c6\u7684\u8ba1\u5212\u3002<br><strong>\u62fc\u51d1\u6838\u5b54\u590d\u5408\u4f53<\/strong><br>\u5728\u6700\u65b0\u4e00\u671f\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u7279\u520a\u4e0a\uff0c\u51e0\u4e2a\u7814\u7a76\u56e2\u961f\u63cf\u8ff0\u4e86 AlphaFold \u5e2e\u52a9\u62fc\u51d1\u6838\u5b54\u590d\u5408\u4f53\u2014\u2014\u751f\u7269\u5b66\u4e2d\u6700\u5177\u6311\u6218\u6027\u7684\u96be\u9898\u4e4b\u4e00\u3002\u8fd9\u4e2a\u5de8\u5927\u7684\u7ed3\u6784\u7531\u6570\u767e\u4e2a\u86cb\u767d\u8d28\u90e8\u5206\u7ec4\u6210\uff0c\u63a7\u5236\u7740\u8fdb\u51fa\u7ec6\u80de\u6838\u7684\u4e00\u5207\u3002<\/p>\n\n\n\n<p>\u4eba\u4eec\u901a\u8fc7\u4f7f\u7528\u73b0\u6709\u7684\u5b9e\u9a8c\u65b9\u6cd5\u63ed\u793a\u5b83\u7684\u8f6e\u5ed3\uff0c\u7ed3\u5408 AlphaFold \u9884\u6d4b\u5b8c\u6210\u548c\u89e3\u91ca\u5176\u4e2d\u4e0d\u6e05\u695a\u7684\u533a\u57df\uff0c\u6700\u7ec8\u63ed\u793a\u4e86\u5b83\u7684\u5fae\u5999\u7ed3\u6784\u3002\u300a\u79d1\u5b66\u300b\u5c06\u5176\u79f0\u4e3a\u5b9e\u9a8c\u7ed3\u6784\u751f\u7269\u5b66\u7684\u80dc\u5229\uff0c\u8fd9\u79cd\u65b0\u7814\u7a76\u65b9\u5f0f\u73b0\u5728\u6b63\u6210\u4e3a\u5b9e\u9a8c\u5ba4\u7684\u5e38\u89c4\u505a\u6cd5\uff0c\u5f00\u542f\u4e86\u65b0\u7684\u79d1\u5b66\u7814\u7a76\u9053\u8def\u3002<br><strong>\u7ed3\u6784\u641c\u7d22\u5de5\u5177<\/strong><br>Foldseek\u3001Dali \u7b49\u7ed3\u6784\u641c\u7d22\u5de5\u5177\u5141\u8bb8\u7528\u6237\u975e\u5e38\u5feb\u901f\u5730\u641c\u7d22\u4e0e\u7ed9\u5b9a\u86cb\u767d\u8d28\u76f8\u4f3c\u7684\u7ed3\u6784\u3002\u8fd9\u5c06\u662f\u4e3a\u5b9e\u9645\u6709\u7528\u7684\u86cb\u767d\u8d28\uff08\u4f8b\u5982\u5206\u89e3\u5851\u6599\u7684\u86cb\u767d\u8d28\uff09\u6316\u6398\u5927\u578b\u5e8f\u5217\u6570\u636e\u96c6\u7684\u7b2c\u4e00\u6b65\uff0c\u5b83\u53ef\u4ee5\u63d0\u4f9b\u6709\u5173\u86cb\u767d\u8d28\u529f\u80fd\u7684\u7ebf\u7d22\u3002<br><strong>\u5bf9\u4eba\u7c7b\u5065\u5eb7\u7684\u5f71\u54cd<\/strong><br>AlphaFold \u5df2\u7ecf\u5bf9\u4eba\u7c7b\u5065\u5eb7\u4ea7\u751f\u4e86\u91cd\u5927\u800c\u76f4\u63a5\u7684\u5f71\u54cd\u3002\u4e0e\u6b27\u6d32\u4eba\u7c7b\u9057\u4f20\u5b66\u4f1a\u7684\u5408\u4f5c\u8bc1\u660e AlphaFold \u5bf9\u4e8e\u89e3\u5f00\u7f55\u89c1\u9057\u4f20\u75be\u75c5\u7684\u539f\u56e0\u81f3\u5173\u91cd\u8981\u3002\u6b64\u5916\uff0cAlphaFold \u8fd8\u901a\u8fc7\u66f4\u597d\u5730\u4e86\u89e3\u65b0\u53d1\u73b0\u7684\u53ef\u80fd\u6210\u4e3a\u836f\u7269\u9776\u70b9\u7684\u86cb\u767d\u8d28\uff0c\u5e2e\u52a9\u79d1\u5b66\u5bb6\u66f4\u5feb\u5730\u627e\u5230\u4e0e\u5176\u7ed3\u5408\u7684\u6f5c\u5728\u836f\u7269\u6765\u52a0\u901f\u836f\u7269\u53d1\u73b0\u3002<br>\u53c2\u8003\u5185\u5bb9\uff1a<em>https:\/\/www.science.org\/doi\/10.1126\/science.add2210<\/em><em>https:\/\/www.theverge.com\/2022\/7\/28\/23280743\/deepmind-alphafold-protein-database-alphabet<\/em><em>https:\/\/www.deepmind.com\/blog\/alphafold-reveals-the-structure-of-the-protein-universe<\/em><em>https:\/\/www.nature.com\/articles\/d41586-022-02083-2<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u81ea&nbsp;\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u5de5\u7a0b\u5e08 \u79d1\u5b66\u754c\u5df2\u77e5\u7684\u51e0\u4e4e\u6240\u6709\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u90fd\u5728\u8fd9\u91cc\u4e86\u3002\u86cb\u767d\u8d28\u662f\u751f\u547d\u7684\u57fa\u7840\u6784\u4ef6\uff0c\u5b83\u4eec\u7531 &hellip; <a href=\"http:\/\/139.9.1.231\/index.php\/2022\/08\/02\/alphafold2-2\/\" class=\"more-link\">\u7ee7\u7eed\u9605\u8bfb<span class=\"screen-reader-text\">AlphaFold2\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"_links":{"self":[{"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/posts\/5181"}],"collection":[{"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/comments?post=5181"}],"version-history":[{"count":4,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/posts\/5181\/revisions"}],"predecessor-version":[{"id":5939,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/posts\/5181\/revisions\/5939"}],"wp:attachment":[{"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/media?parent=5181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/categories?post=5181"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/tags?post=5181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}