{"id":5940,"date":"2022-08-21T18:08:47","date_gmt":"2022-08-21T10:08:47","guid":{"rendered":"http:\/\/139.9.1.231\/?p=5940"},"modified":"2022-08-21T18:08:51","modified_gmt":"2022-08-21T10:08:51","slug":"properties-of-proteins","status":"publish","type":"post","link":"http:\/\/139.9.1.231\/index.php\/2022\/08\/21\/properties-of-proteins\/","title":{"rendered":"\u7528\u8bed\u8a00\u6a21\u578b\u5b66\u4e60\u8868\u793a\u86cb\u767d\u8d28\u7684\u529f\u80fd\u7279\u6027"},"content":{"rendered":"\n<p>\u4ee5\u6570\u636e\u4e3a\u4e2d\u5fc3\u7684\u65b9\u6cd5\u5df2\u88ab\u7528\u4e8e\u5f00\u53d1\u7528\u4e8e\u9610\u660e\u86cb\u767d\u8d28\u672a\u8868\u5f81\u7279\u6027\u7684\u9884\u6d4b\u65b9\u6cd5\uff1b\u7136\u800c\uff0c\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u5e94\u8fdb\u4e00\u6b65\u6539\u8fdb\uff0c\u4ee5\u6709\u6548\u89e3\u51b3\u751f\u7269\u533b\u5b66\u548c\u751f\u7269\u6280\u672f\u4e2d\u7684\u5173\u952e\u95ee\u9898\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u66f4\u597d\u5730\u4ee3\u8868\u624b\u5934\u7684\u6570\u636e\u6765\u5b9e\u73b0\u3002\u65b0\u7684\u6570\u636e\u8868\u793a\u65b9\u6cd5\u4e3b\u8981\u4ece\u5728\u81ea\u7136\u8bed\u8a00\u5904\u7406\u65b9\u9762\u53d6\u5f97\u7a81\u7834\u6027\u6539\u8fdb\u7684\u8bed\u8a00\u6a21\u578b\u4e2d\u6c72\u53d6\u7075\u611f\u3002\u6700\u8fd1\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u5df2\u5e94\u7528\u4e8e\u86cb\u767d\u8d28\u79d1\u5b66\u9886\u57df\uff0c\u5e76\u5728\u63d0\u53d6\u590d\u6742\u7684\u5e8f\u5217-\u7ed3\u6784-\u529f\u80fd\u5173\u7cfb\u65b9\u9762\u663e\u793a\u51fa\u975e\u5e38\u6709\u5e0c\u671b\u7684\u7ed3\u679c\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u571f\u8033\u5176\u4e2d\u4e1c\u79d1\u6280\u5927\u5b66\uff08Middle East Technical University\uff09\u7684\u7814\u7a76\u4eba\u5458\uff0c\u9996\u5148\u5bf9\u6bcf\u79cd\u65b9\u6cd5\u8fdb\u884c\u5206\u7c7b\/\u89e3\u91ca\uff0c\u7136\u540e\u5bf9\u5b83\u4eec\u7684\u9884\u6d4b\u6027\u80fd\u8fdb\u884c\u57fa\u51c6\u6d4b\u8bd5\uff0c\u5bf9\u86cb\u767d\u8d28\u8868\u793a\u5b66\u4e60\u8fdb\u884c\u4e86\u8be6\u7ec6\u8c03\u67e5\uff1a\uff081\uff09\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u8bed\u4e49\u76f8\u4f3c\u6027\uff0c\uff082\uff09\u57fa\u4e8e\u672c\u4f53\u7684\u86cb\u767d\u8d28\u529f\u80fd\uff0c\uff083\uff09\u836f\u7269\u9776\u86cb\u767d\u5bb6\u65cf\u548c\uff084\uff09\u7a81\u53d8\u540e\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u7ed3\u5408\u4eb2\u548c\u529b\u7684\u53d8\u5316\u3002\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u8bba\u5c06\u6709\u52a9\u4e8e\u7814\u7a76\u4eba\u5458\u5c06\u57fa\u4e8e\u673a\u5668\/\u6df1\u5ea6\u5b66\u4e60\u7684\u8868\u793a\u6280\u672f\u5e94\u7528\u4e8e\u86cb\u767d\u8d28\u6570\u636e\u4ee5\u8fdb\u884c\u5404\u79cd\u9884\u6d4b\u4efb\u52a1\uff0c\u5e76\u6fc0\u53d1\u65b0\u65b9\u6cd5\u7684\u53d1\u5c55\u3002\u8be5\u7814\u7a76\u4ee5\u300c<em>Learning functional properties of proteins with language models<\/em>\u300d\u4e3a\u9898\uff0c\u4e8e 2022 \u5e74 3 \u6708 21 \u65e5\u53d1\u5e03\u5728\u300a<em>Nature Machine Intelligence<\/em>\u300b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" width=\"997\" height=\"331\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-231.png\" alt=\"\" class=\"wp-image-5941\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-231.png 997w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-231-300x100.png 300w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-231-768x255.png 768w\" sizes=\"(max-width: 997px) 100vw, 997px\" \/><\/figure>\n\n\n\n<p>\u86cb\u767d\u8d28\u79d1\u5b66\u662f\u4e00\u95e8\u5e7f\u6cdb\u7684\u5b66\u79d1\uff0c\u5b83\u901a\u8fc7\u5b9e\u9a8c\u5ba4\u5b9e\u9a8c\uff08\u5373\u86cb\u767d\u8d28\u7ec4\u5b66\uff09\u548c\u8ba1\u7b97\u65b9\u6cd5\uff08\u4f8b\u5982\u5206\u5b50\u5efa\u6a21\u3001\u673a\u5668\u5b66\u4e60\u3001\u6570\u636e\u79d1\u5b66\uff09\u5206\u6790\u5355\u4e2a\u86cb\u767d\u8d28\u4ee5\u53ca\u751f\u7269\u4f53\u7684\u6574\u4e2a\u86cb\u767d\u8d28\u7ec4\uff0c\u6700\u7ec8\u521b\u5efa\u51c6\u786e\u4e14\u53ef\u91cd\u590d\u4f7f\u7528\u7684\u65b9\u6cd5\u7528\u4e8e\u751f\u7269\u533b\u5b66\u548c\u751f\u7269\u6280\u672f\u3002\u86cb\u767d\u8d28\u4fe1\u606f\u5b66\u53ef\u4ee5\u5b9a\u4e49\u4e3a\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u8ba1\u7b97\u548c\u4ee5\u6570\u636e\u4e3a\u4e2d\u5fc3\u7684\u5206\u652f\uff0c\u901a\u8fc7\u5b83\u5bf9\u86cb\u767d\u8d28\u7684\u5b9a\u91cf\u65b9\u9762\u8fdb\u884c\u5efa\u6a21\u3002\u86cb\u767d\u8d28\u7684\u529f\u80fd\u8868\u5f81\u5bf9\u4e8e\u5f00\u53d1\u65b0\u7684\u6709\u6548\u7684\u751f\u7269\u533b\u5b66\u7b56\u7565\u548c\u751f\u7269\u6280\u672f\u4ea7\u54c1\u81f3\u5173\u91cd\u8981\u3002\u622a\u81f3 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(NLP) \u65b9\u6cd5\u7684\u542f\u53d1\u3002\u56e0\u6b64\uff0c\u86cb\u767d\u8d28\u8868\u793a\u5b66\u4e60\u65b9\u6cd5\u5728\u6587\u732e\u4e2d\u7ecf\u5e38\u88ab\u79f0\u4e3a\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u3002\u4e4b\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u5404\u79cd\u86cb\u767d\u8d28\u8868\u793a\u5b66\u4e60\u65b9\u6cd5\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u7ed3\u5408\u4e86\u6df1\u5ea6\u5b66\u4e60\u7684\u65b9\u6cd5\uff0c\u5df2\u7ecf\u6210\u529f\u5730\u63d0\u53d6\u4e86\u86cb\u767d\u8d28\u7684\u76f8\u5173\u56fa\u6709\u7279\u5f81\u3002\u53c2\u89c1\uff1a<em>https:\/\/www.nature.com\/articles\/s42256-022-00457-9\/tables\/1<\/em>\u5c3d\u7ba1\u6709\u7814\u7a76\u8bc4\u4f30\u5b66\u4e60\u7684\u86cb\u767d\u8d28\u8868\u793a\u6a21\u578b\uff0c\u4f46\u9700\u8981\u8fdb\u884c\u5168\u9762\u7684\u8c03\u67e5\u548c\u57fa\u51c6\u6d4b\u8bd5\uff0c\u4ee5\u4fbf\u5728\u5b66\u4e60\u86cb\u767d\u8d28\u7684\u591a\u4e2a\u65b9\u9762\uff08\u5305\u62ec\u57fa\u4e8e\u672c\u4f53\u7684\u529f\u80fd\u5b9a\u4e49\u3001\u8bed\u4e49\u5173\u7cfb\u3001\u5bb6\u65cf\u548c\u76f8\u4e92\u4f5c\u7528\uff09\u7684\u80cc\u666f\u4e0b\u7cfb\u7edf\u5730\u8bc4\u4f30\u8fd9\u4e9b\u65b9\u6cd5\u3002\u5728\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u4e2d\u4e1c\u79d1\u6280\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5bf9\u81ea 2015 \u5e74\u4ee5\u6765\u63d0\u51fa\u7684\u53ef\u7528\u86cb\u767d\u8d28\u8868\u793a\u5b66\u4e60\u65b9\u6cd5\u8fdb\u884c\u4e86\u5168\u9762\u8c03\u67e5\uff0c\u5e76\u901a\u8fc7\u8be6\u7ec6\u7684\u57fa\u51c6\u5206\u6790\u6d4b\u91cf\u4e86\u8fd9\u4e9b\u65b9\u6cd5\u6355\u83b7\u86cb\u767d\u8d28\u529f\u80fd\u7279\u6027\u7684\u6f5c\u529b\u3002\u6db5\u76d6\u4e86\u7ecf\u5178\u548c\u57fa\u4e8e\u4eba\u5de5\u5b66\u4e60\u7684\u65b9\u6cd5\uff0c\u5e76\u6df1\u5165\u4e86\u89e3\u4e86\u5b83\u4eec\u5404\u81ea\u4ee3\u8868\u86cb\u767d\u8d28\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u4eba\u5458\u6839\u636e\u5b83\u4eec\u7684\u6280\u672f\u7279\u5f81\u548c\u5e94\u7528\u5bf9\u8fd9\u4e9b\u65b9\u6cd5\u8fdb\u884c\u5206\u7c7b\u3002\u4e3a\u4e86\u8bc4\u4f30\u6bcf\u4e2a\u8868\u793a\u6a21\u578b\u5728\u591a\u5927\u7a0b\u5ea6\u4e0a\u6355\u83b7\u4e86\u529f\u80fd\u4fe1\u606f\u7684\u4e0d\u540c\u65b9\u9762\uff0c\u8be5\u56e2\u961f\u6784\u5efa\u5e76\u5e94\u7528\u4e86\u57fa\u4e8e\u4ee5\u4e0b\u7684\u57fa\u51c6\uff1a(1) \u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u8bed\u4e49\u76f8\u4f3c\u6027\u63a8\u65ad\uff0c(2) \u57fa\u4e8e\u672c\u4f53\u7684 PFP\uff0c(3) \u836f\u7269\u9776\u86cb\u767d\u5bb6\u65cf\u5206\u7c7b\uff0c(4) \u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u7ed3\u5408\u4eb2\u548c\u529b\u4f30\u8ba1\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"994\" height=\"1024\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-232-994x1024.png\" alt=\"\" class=\"wp-image-5942\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-232-994x1024.png 994w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-232-291x300.png 291w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-232-768x791.png 768w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-232.png 1109w\" sizes=\"(max-width: 994px) 100vw, 994px\" \/><\/figure>\n\n\n\n<p>\u56fe\u793a\uff1a\u7814\u7a76\u7684\u793a\u610f\u56fe\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09\u6b64\u5916\uff0c\u8be5\u56e2\u961f\u8fd8\u63d0\u4f9b\u4e86\u76f8\u5173\u7684\u57fa\u51c6\u6d4b\u8bd5\u8f6f\u4ef6\uff08Protein Representation Benchmark, PROBE\uff09\uff0c\u5b83\u5141\u8bb8\u4eba\u4eec\u8f7b\u677e\u8bc4\u4f30\u4efb\u4f55\u8868\u793a\u65b9\u6cd5\u5728\u8be5\u56e2\u961f\u5b9a\u4e49\u7684\u56db\u4e2a\u57fa\u51c6\u6d4b\u8bd5\u4efb\u52a1\u4e2d\u7684\u6027\u80fd\u3002\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u8be5\u5de5\u4f5c\u80fd\u591f\uff0c\u4e3a\u5e0c\u671b\u5c06\u57fa\u4e8e\u673a\u5668\/\u6df1\u5ea6\u5b66\u4e60\u7684\u8868\u793a\u6280\u672f\uff0c\u5e94\u7528\u4e8e\u751f\u7269\u5206\u5b50\u6570\u636e\u8fdb\u884c\u9884\u6d4b\u5efa\u6a21\u7684\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4fe1\u606f\u3002\u4e5f\u5e0c\u671b\u8fd9\u9879\u7814\u7a76\u80fd\u591f\u6fc0\u53d1\u65b0\u7684\u60f3\u6cd5\uff0c\u4ee5\u5f00\u53d1\u65b0\u9896\u3001\u590d\u6742\u548c\u5f3a\u5927\u7684\u4ee5\u6570\u636e\u4e3a\u4e2d\u5fc3\u7684\u65b9\u6cd5\u6765\u89e3\u51b3\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u7684\u5f00\u653e\u95ee\u9898\u3002<strong>\u57fa\u4e8e\u8868\u793a\u5b66\u4e60\u7684\u65b9\u6cd5\u5728\u86cb\u767d\u8d28\u529f\u80fd\u5206\u6790\u4e2d\u7684\u8868\u73b0\u901a\u5e38\u4f18\u4e8e\u7ecf\u5178\u65b9\u6cd5<\/strong>\u5728\u8be5\u56e2\u961f\u6240\u6709\u7684\u57fa\u51c6\u6d4b\u8bd5\u4e2d\uff0c\u89c2\u5bdf\u5230\u5b66\u4e60\u8868\u793a\uff08\u5c24\u5176\u662f\u5927\u578b\u6a21\u578b\uff09\u5728\u9884\u6d4b\u6027\u80fd\u65b9\u9762\u4f18\u4e8e\u7ecf\u5178\u6a21\u578b\uff0c\u8bc1\u5b9e\u4e86\u57fa\u4e8e\u4eba\u5de5\u5b66\u4e60\u7684\u6570\u636e\u9a71\u52a8\u65b9\u6cd5\u5728\u8868\u793a\u751f\u7269\u5206\u5b50\u7684\u529f\u80fd\u7279\u6027\u65b9\u9762\u7684\u4f18\u52bf\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5728 PFP \u9884\u6d4b\u57fa\u51c6\u7684\u5206\u5b50\u529f\u80fd\u7c7b\u522b\u4e2d\uff0cHMMER \u662f\u4e00\u79cd\u57fa\u4e8e\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\uff08HMM\uff09\u7684\u751f\u7269\u5206\u5b50\u76f8\u4f3c\u6027\u68c0\u6d4b\u548c\u529f\u80fd\u6ce8\u91ca\u7684\u7ecf\u5178\u65b9\u6cd5\uff0c\u53ef\u4ee5\u4e0e\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u86cb\u767d\u8d28\u8868\u793a\u65b9\u6cd5\u7ade\u4e89\u3002\u8be5\u7ed3\u679c\u4e0e\u5148\u524d\u7684\u7814\u7a76\u4e00\u81f4\uff0c\u5373\u5e8f\u5217\u76f8\u4f3c\u6027\u4e0e\u86cb\u767d\u8d28\u7684\u751f\u5316\u7279\u6027\u9ad8\u5ea6\u76f8\u5173\uff0c\u4ee5\u81f3\u4e8e\u4f7f\u7528\u6b64\u7279\u5f81\u7684\u7b80\u5355\u77e2\u91cf\u8868\u793a\u51e0\u4e4e\u53ef\u4ee5\u6267\u884c\u590d\u6742\u7684\u5e8f\u5217\u5efa\u6a21\u65b9\u6cd5\u3002\u9274\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0c\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u5c06\u540c\u6e90\u4fe1\u606f\u660e\u786e\u7eb3\u5165\u8868\u5f81\u5b66\u4e60\u6a21\u578b\u7684\u8bad\u7ec3\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8003\u8651\u5230\u9884\u6d4b\u6027\u80fd\u7684\u6539\u8fdb\u3002\u8fd9\u4ece\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u9ad8\u6027\u80fd\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u5668\uff08\u4f8b\u5982 RoseTTAFold \u548c AlphaFold2\uff09\u4e2d\u4e5f\u5f88\u660e\u663e\uff0c\u5b83\u4eec\u4f7f\u7528\u591a\u4e2a\u5e8f\u5217\u6bd4\u5bf9\u6765\u663e\u7740\u4e30\u5bcc\u57fa\u4e8e\u5e8f\u5217\u7684\u8f93\u5165\u3002\u4ed6\u4eec\u8ba4\u4e3a\uff0c\u5728\u5f53\u524d\u72b6\u6001\u4e0b\uff0c\u5b66\u4e60\u5230\u7684\u86cb\u767d\u8d28\u8868\u793a\u5bf9\u4e8e\u5176\u4ed6\u539f\u56e0\u4e5f\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002<strong>\u6a21\u578b\u8bbe\u8ba1\u548c\u8bad\u7ec3\u6570\u636e\u7c7b\u578b\/\u6765\u6e90\u662f\u8868\u5f81\u5b66\u4e60\u7684\u5173\u952e\u56e0\u7d20<\/strong>\u86cb\u767d\u8d28\u8868\u5f81\u5b66\u4e60\u4e2d\u6700\u5173\u952e\u7684\u56e0\u7d20\u4e4b\u4e00\u662f\u8868\u5f81\u6a21\u578b\u7684\u8bbe\u8ba1\u3002\u4f8b\u5982\uff0c\u5728\u8fd9\u91cc\u7684\u57fa\u51c6\u6d4b\u8bd5\u4e2d\uff0c\u5305\u542b\u4e86\u4e24\u79cd\u7c7b\u578b\u7684 BERT \u6a21\u578b\u3002TAPE-BERT-PFAM \u63a5\u53d7\u4e86 3200 \u4e07\u4e2a\u86cb\u767d\u8d28\u7ed3\u6784\u57df\u5e8f\u5217\u7684\u8bad\u7ec3\u3002ProtBERT-BFD \u8bad\u7ec3\u6709 21 \u4ebf\u4e2a\u5b8f\u57fa\u56e0\u7ec4\u5e8f\u5217\u7247\u6bb5\uff1b\u7136\u800c\uff0c\u8fd9\u4e24\u8005\u4e4b\u95f4\u7684\u6027\u80fd\u5dee\u5f02\u662f\u5fae\u4e0d\u8db3\u9053\u7684\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u4f7f\u7528\u76f8\u540c 2.1B \u6570\u636e\u96c6\uff08\u4f8b\u5982 ProtT5-XL\uff09\u8bad\u7ec3\u7684\u66f4\u590d\u6742\u7684\u6a21\u578b\u5728\u5927\u591a\u6570\u57fa\u51c6\u6d4b\u8bd5\u4e2d\u8868\u73b0\u51fa\u66f4\u597d\u7684\u6027\u80fd\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u6a21\u578b\u8bbe\u8ba1\/\u67b6\u6784\u662f\u6700\u91cd\u8981\u7684\uff08\u4e0e\u8fd9\u4e9b\u65b9\u6cd5\u7684\u8bbe\u8ba1\/\u67b6\u6784\u76f8\u5173\u7684\u4fe1\u606f\u5728\u65b9\u6cd5\u4e2d\u7ed9\u51fa\uff0c\u5e76\u5728\u7ed3\u679c\u90e8\u5206\u5c31\u9884\u6d4b\u6027\u80fd\u8fdb\u884c\u4e86\u8ba8\u8bba\uff09\u3002\u5173\u4e8e\u8bad\u7ec3\u6570\u636e\u6e90\u7684\u53e6\u4e00\u4e2a\u53d1\u73b0\u662f\uff0c\u5408\u5e76\u591a\u79cd\u6570\u636e\u7c7b\u578b\u53ef\u80fd\u4f1a\u5728\u4e0e\u529f\u80fd\u76f8\u5173\u7684\u9884\u6d4b\u4efb\u52a1\u4e2d\u5e26\u6765\u66f4\u597d\u7684\u6027\u80fd\u3002\u4f8b\u5982\uff0cAAC \u548c APAAC \u90fd\u4f7f\u7528\u6c28\u57fa\u9178\u7ec4\u6210\uff1b\u7136\u800c\uff0cAPAAC \u8fd8\u5728\u5176\u8868\u793a\u6a21\u578b\u4e2d\u6dfb\u52a0\u4e86\u7269\u7406\u5316\u5b66\u7279\u6027\uff0c\u5e76\u4e14\u5728\u8bed\u4e49\u76f8\u4f3c\u6027\u63a8\u65ad\u548c PFP \u57fa\u51c6\u6d4b\u8bd5\u4e2d\u8868\u73b0\u5f97\u66f4\u597d\u3002\u540c\u6837\uff0cMut2Vec \u7ed3\u5408\u4e86\u7a81\u53d8\u914d\u7f6e\u6587\u4ef6\u3001PPI \u548c\u6587\u672c\u6570\u636e\uff0c\u5e76\u53d6\u5f97\u4e86\u6700\u4f73\u6027\u80fd\uff1b\u5c24\u5176\u662f\u5728\u8bed\u4e49\u76f8\u4f3c\u6027\u63a8\u7406\u57fa\u51c6\u6d4b\u8bd5\u4e2d\u3002<strong>\u5728\u86cb\u767d\u8d28\u8868\u5f81\u5b66\u4e60\u65b9\u6cd5\u7684\u6784\u5efa\u548c\u8bc4\u4f30\u8fc7\u7a0b\u4e2d\u5e94\u8003\u8651\u6f5c\u5728\u7684\u6570\u636e\u6cc4\u6f0f<\/strong>\u6570\u636e\u6cc4\u6f0f\u53ef\u4ee5\u5b9a\u4e49\u4e3a\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7684\u8bad\u7ec3\u548c\u9a8c\u8bc1\u9636\u6bb5\u4e4b\u95f4\u7684\u77e5\u8bc6\u610f\u5916\u6cc4\u6f0f\uff0c\u5bfc\u81f4\u6027\u80fd\u6d4b\u91cf\u8fc7\u4e8e\u4e50\u89c2\uff0c\u662f\u6027\u80fd\u6d4b\u8bd5\u671f\u95f4\u5e94\u8003\u8651\u7684\u5173\u952e\u95ee\u9898\u3002\u7814\u7a76\u4eba\u5458\u5206\u6790\u53d1\u73b0\uff0c\u67d0\u4e9b\u8868\u793a\u6a21\u578b\u5728\u4e0e\u8fd9\u4e9b\u6a21\u578b\u9884\u8bad\u7ec3\u7684\u4efb\u52a1\u751f\u7269\u5b66\u76f8\u5173\u7684\u4efb\u52a1\u4e2d\u8868\u73b0\u826f\u597d\uff1b\u5c3d\u7ba1\u6570\u636e\u548c\u5b9e\u9645\u4efb\u52a1\u5f7c\u6b64\u4e0d\u540c\u3002<strong>\u86cb\u767d\u8d28\u8868\u5f81\u5b66\u4e60\u7684\u73b0\u72b6\u548c\u6311\u6218<\/strong>\u86cb\u767d\u8d28\u8868\u793a\u5b66\u4e60\u9886\u57df\u5b58\u5728\u4e00\u4e9b\u6311\u6218\u3002\u5c3d\u7ba1\u5927\u591a\u6570\u86cb\u767d\u8d28\u8868\u793a\u5b66\u4e60\u6a21\u578b\uff08\u8fc4\u4eca\u4e3a\u6b62\u63d0\u51fa\u7684\uff09\u90fd\u662f\u6e90\u81ea NLP \u6a21\u578b\uff08\u57fa\u4e8e LSTM\/transformer \u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff09\uff0c\u4f46\u5efa\u6a21\u8bed\u8a00\u548c\u86cb\u767d\u8d28\u7684\u95ee\u9898\u4e4b\u95f4\u5b58\u5728\u7ed3\u6784\u5dee\u5f02\u3002\u636e\u4f30\u8ba1\uff0c\u4e00\u4e2a\u4ee5\u7f8e\u56fd\u4e3a\u6bcd\u8bed\u7684\u6210\u5e74\u82f1\u8bed\u4f7f\u7528\u8005\uff0c\u5e73\u5747\u4f7f\u7528 46,200 \u4e2a\u8bcd\u6761\u548c\u591a\u8bcd\u8868\u8fbe\uff1b\u7136\u800c\uff0c\u86cb\u767d\u8d28\u4e2d\u53ea\u6709 20 \u79cd\u4e0d\u540c\u7684\u6c28\u57fa\u9178\uff0c\u5b83\u4eec\u88ab\u8868\u793a\u6a21\u578b\u4ee5\u7c7b\u4f3c\u4e8e\u8bed\u8a00\u7684\u5f15\u7406\u7684\u65b9\u5f0f\u5904\u7406\u3002\u8fd9\u4e9b NLP \u6a21\u578b\u4e3a\u6bcf\u4e2a\u5355\u8bcd\u8ba1\u7b97\u4e00\u4e2a\u8868\u793a\u5411\u91cf\u3002\u7c7b\u4f3c\u5730\uff0c\u5f53\u8fd9\u79cd\u65b9\u6cd5\u5e94\u7528\u4e8e\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u65f6\uff0c\u4f1a\u4e3a\u6bcf\u4e2a\u6c28\u57fa\u9178\u8ba1\u7b97\u4e00\u4e2a\u8868\u793a\u5411\u91cf\u3002\u8fd9\u4e9b\u5411\u91cf\u88ab\u6c47\u96c6\u8d77\u6765\uff0c\u4e3a\u6bcf\u4e2a\u53e5\u5b50\/\u6587\u6863\u548c\u86cb\u767d\u8d28\u521b\u5efa\u56fa\u5b9a\u5927\u5c0f\u7684\u5411\u91cf\uff0c\u5206\u522b\u7528\u4e8e NLP \u548c\u86cb\u767d\u8d28\u4fe1\u606f\u5b66\u4efb\u52a1\u3002\u56e0\u6b64\uff0c\u4e0e NLP \u76f8\u6bd4\uff0c\u86cb\u767d\u8d28\u8868\u793a\u4e2d\u7684\u5c11\u91cf\u6784\u5efa\u5757\uff08\u5373 20 \u4e2a\u6c28\u57fa\u9178\uff09\u53ef\u80fd\u4e3a\u8f83\u5c0f\u7684\u6a21\u578b\u5728\u4e0e\u86cb\u767d\u8d28\u8868\u793a\u5b66\u4e60\u9886\u57df\u4e2d\u7684\u8f83\u5927\u6a21\u578b\u7ade\u4e89\u65f6\u5e26\u6765\u4f18\u52bf\u3002\u56e0\u6b64\uff0c\u9f13\u52b1\u5bf9\u86cb\u767d\u8d28\u5e8f\u5217\u7279\u5f02\u6027\u5b66\u4e60\u6a21\u578b\u8fdb\u884c\u66f4\u591a\u7814\u7a76\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"1024\" height=\"954\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-233-1024x954.png\" alt=\"\" class=\"wp-image-5943\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-233-1024x954.png 1024w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-233-300x279.png 300w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-233-768x715.png 768w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-233.png 1033w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u56fe\u793a\uff1a\u86cb\u767d\u8d28\u8bed\u4e49\u76f8\u4f3c\u6027\u63a8\u7406\u57fa\u51c6\u7ed3\u679c\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09\u6a21\u578b\u7684\u53ef\u89e3\u91ca\u6027\u5bf9\u4e8e\u7406\u89e3\u6a21\u578b\u4e3a\u4f55\u5982\u6b64\u884c\u4e8b\u81f3\u5173\u91cd\u8981\u3002\u5728\u53ef\u89e3\u91ca\u8868\u793a\u4e2d\uff0c\u6240\u6709\u7279\u5f81\u90fd\u4ee5\u9694\u79bb\u5f62\u5f0f\u7f16\u7801\uff0c\u8fd9\u610f\u5473\u7740\u5411\u91cf\u4e0a\u6bcf\u4e2a\u4f4d\u7f6e\u5bf9\u5e94\u7684\u7279\u5f81\u662f\u5df2\u77e5\u7684\uff1b\u7136\u800c\uff0c\u8be5\u7814\u7a76\u4e2d\u7814\u7a76\u7684\u5927\u591a\u6570\u5b66\u4e60\u86cb\u767d\u8d28\u8868\u793a\u662f\u4e0d\u53ef\u89e3\u91ca\/\u53ef\u89e3\u91ca\u7684\u3002\u4f8b\u5982\uff0c\u86cb\u767d\u8d28\u4e2d TIM \u6876\u7ed3\u6784\u7684\u5b58\u5728\u53ef\u80fd\u5728\u5176\u8868\u793a\u5411\u91cf\u7684\u7b2c\u4e94\u4f4d\u7f16\u7801\uff0c\u800c\u5206\u5b50\u91cf\u4fe1\u606f\u53ef\u80fd\u5728\u7b2c\u4e09\u548c\u7b2c\u56db\u4f4d\u4e4b\u95f4\u5171\u4eab\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u5728\u6570\u636e\u79d1\u5b66\u9886\u57df\uff0c\u89e3\u7f20\u7ed3\u7814\u7a76\u8bd5\u56fe\u5c06\u6837\u672c\u7684\u771f\u5b9e\u5c5e\u6027\u4e0e\u8f93\u51fa\u5411\u91cf\u7684\u5404\u4e2a\u4f4d\u7f6e\u8054\u7cfb\u8d77\u6765\u3002\u86cb\u767d\u8d28\u8868\u5f81\u7684\u89e3\u5f00\u662f\u4e00\u4e2a\u65b0\u8bfe\u9898\uff0c\u8fc4\u4eca\u4e3a\u6b62\u53ea\u6709\u5c11\u6570\u8868\u5f81\u6a21\u578b\u5f00\u53d1\u4eba\u5458\u63a2\u8ba8\u4e86\u8fd9\u4e2a\u95ee\u9898\u3002\u56e0\u6b64\uff0c\u5c1a\u4e0d\u5b58\u5728\u7cfb\u7edf\u65b9\u6cd5\uff0c\u5e76\u4e14\u9700\u8981\u65b0\u7684\u6846\u67b6\u6765\u6807\u51c6\u5316\u8bc4\u4f30\u86cb\u767d\u8d28\u8868\u793a\u6a21\u578b\u7684\u53ef\u89e3\u91ca\u6027\u3002\u8fc4\u4eca\u4e3a\u6b62\u63d0\u51fa\u7684\u5927\u591a\u6570\u86cb\u767d\u8d28\u8868\u793a\u6a21\u578b\u4ec5\u4f7f\u7528\u4e00\u79cd\u7c7b\u578b\u7684\u6570\u636e\uff08\u4f8b\u5982\u86cb\u767d\u8d28\u5e8f\u5217\uff09\u8fdb\u884c\u8bad\u7ec3\u3002\u7136\u800c\uff0c\u86cb\u767d\u8d28\u77e5\u8bc6\u4e0e\u591a\u79cd\u7c7b\u578b\u7684\u751f\u7269\u4fe1\u606f\u76f8\u5173\uff0c\u4f8b\u5982 PPI\u3001\u7ffb\u8bd1\u540e\u4fee\u9970\u3001\u57fa\u56e0\/\u86cb\u767d\u8d28\uff08\u5171\uff09\u8868\u8fbe\u7b49\uff1b\u53ea\u6709\u5c11\u6570\u53ef\u7528\u7684\u86cb\u767d\u8d28\u8868\u793a\u6a21\u578b\u4f7f\u7528\u4e86\u591a\u79cd\u7c7b\u578b\u7684\u6570\u636e\u3002\u5728\u8be5\u56e2\u961f\u7684\u57fa\u51c6\u7814\u7a76\u65f6\u6240\u6d89\u53ca\u7684\u65b9\u6cd5\u4e2d\uff0cMut2Vec \u5c31\u662f\u4e00\u4e2a\u8fd9\u6837\u7684\u4f8b\u5b50\uff0c\u5b83\u7ed3\u5408\u4e86 PPI\u3001\u7a81\u53d8\u548c\u751f\u7269\u533b\u5b66\u6587\u672c\uff0c\u5e76\u4e14\u6bd4 GO BP \u548c\u57fa\u4e8e CC \u7684 PFP \u4e2d\u7684\u8bb8\u591a\u4ec5\u57fa\u4e8e\u5e8f\u5217\u7684\u8868\u793a\u4ea7\u751f\u4e86\u66f4\u51c6\u786e\u7684\u7ed3\u679c\u3002\u7814\u7a76\u4eba\u5458\u5efa\u8bae\u6574\u5408\u5176\u4ed6\u7c7b\u578b\u7684\u86cb\u767d\u8d28\u76f8\u5173\u6570\u636e\uff0c\u5c24\u5176\u662f\u8fdb\u5316\u5173\u7cfb\uff0c\u53ef\u80fd\u4f1a\u8fdb\u4e00\u6b65\u63d0\u9ad8\u9884\u6d4b\u4efb\u52a1\u7684\u51c6\u786e\u6027\u3002MSA-Transformer \u548c\u65e0\u5411\u56fe\u6a21\u578b\uff08\u4f8b\u5982 DeepSequence\uff09\u901a\u8fc7\u6df1\u5ea6\u5b66\u4e60\u5229\u7528\u540c\u6e90\u4fe1\u606f\u3002DeepSequence \u4f7f\u7528 MSA \u7684\u540e\u9a8c\u5206\u5e03\u8ba1\u7b97\u6f5c\u5728\u56e0\u5b50\uff0c\u800c MSA-Transformer \u4f7f\u7528\u57fa\u4e8e\u884c\u548c\u5217\u7684\u6ce8\u610f\u529b\u6765\u7ed3\u5408 MSA \u548c\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u3002\u5c3d\u7ba1 MSA-Transformer \u5728\u57fa\u51c6\u6d4b\u8bd5\u4e2d\u8868\u73b0\u51fa\u5e73\u5747\u6027\u80fd\uff0c\u4f46\u5728\u4e4b\u524d\u7684\u6587\u732e\u4e2d\uff0c\u53d1\u73b0\u5b83\u5728\u4e8c\u7ea7\u7ed3\u6784\u548c\u63a5\u89e6\u9884\u6d4b\u4efb\u52a1\u4e0a\u662f\u6210\u529f\u7684\uff0c\u8fd9\u8868\u660e MSA-Transformer 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class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"843\" height=\"1024\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-234-843x1024.png\" alt=\"\" class=\"wp-image-5944\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-234-843x1024.png 843w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-234-247x300.png 247w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-234-768x933.png 768w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-234.png 997w\" sizes=\"(max-width: 843px) 100vw, 843px\" 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\u4e2a\u6c28\u57fa\u9178\uff0c\u5176\u4e2d\u5b58\u5728 20^350 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Rosetta\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u57fa\u4e8e\u4eba\u5de5\u5b66\u4e60\u7684\u751f\u6210\u5efa\u6a21\u53ef\u7528\u4e8e\u4ece\u5934\u86cb\u767d\u8d28\u8bbe\u8ba1\u3002\u5728\u673a\u5668\u5b66\u4e60\u9886\u57df\uff0c\u751f\u6210\u5efa\u6a21\u4e0e\u5224\u522b\u5efa\u6a21\u76f8\u53cd\uff0c\u662f\u4e00\u79cd\u751f\u6210\u5408\u6210\u6837\u672c\u7684\u65b9\u6cd5\uff0c\u8fd9\u4e9b\u6837\u672c\u670d\u4ece\u4ece\u771f\u5b9e\u6837\u672c\u4e2d\u5b66\u4e60\u5230\u7684\u6982\u7387\u5206\u5e03\u3002\u8fd9\u662f\u901a\u8fc7\u6709\u6548\u5730\u5b66\u4e60\u8bad\u7ec3\u6570\u636e\u96c6\u4e2d\u6837\u672c\u7684\u8868\u793a\u6765\u5b9e\u73b0\u7684\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"978\" height=\"1024\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-235-978x1024.png\" alt=\"\" class=\"wp-image-5945\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-235-978x1024.png 978w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-235-287x300.png 287w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-235-768x804.png 768w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-235.png 998w\" sizes=\"(max-width: 978px) 100vw, 978px\" \/><\/figure>\n\n\n\n<p>\u56fe\u793a\uff1a\u836f\u7269\u9776\u86cb\u767d\u5bb6\u65cf\u5206\u7c7b\u57fa\u51c6\u7ed3\u679c\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09\u6df1\u5ea6\u5b66\u4e60\u6700\u8fd1\u5df2\u6210\u4e3a\u751f\u6210\u6a21\u578b\u67b6\u6784\u7684\u5173\u952e\u65b9\u6cd5\uff0c\u5e76\u5df2\u5e94\u7528\u4e8e\u5305\u62ec\u86cb\u767d\u8d28\/\u80bd\u8bbe\u8ba1\u5728\u5185\u7684\u5404\u4e2a\u9886\u57df\u3002\u4f8b\u5982\uff0cMadani \u56e2\u961f\u4f7f\u7528\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u4ece\u5934\u5f00\u59cb\u8bbe\u8ba1\u5c5e\u4e8e\u4e0d\u540c\u86cb\u767d\u8d28\u5bb6\u65cf\u7684\u65b0\u529f\u80fd\u86cb\u767d\u8d28\uff0c\u5e76\u901a\u8fc7\u6e7f\u5b9e\u9a8c\u5ba4\u5b9e\u9a8c\u9a8c\u8bc1\u4e86\u4ed6\u4eec\u7684\u8bbe\u8ba1\u3002\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\uff0c\u8868\u793a\u5b66\u4e60\u5bf9\u4e8e\u86cb\u767d\u8d28\u548c\u914d\u4f53\uff08\u836f\u7269\uff09\u8bbe\u8ba1\u4e2d\u7684\u65b0\u5e94\u7528\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"1024\" height=\"637\" src=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-236-1024x637.png\" alt=\"\" class=\"wp-image-5946\" srcset=\"http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-236-1024x637.png 1024w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-236-300x187.png 300w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-236-768x478.png 768w, http:\/\/139.9.1.231\/wp-content\/uploads\/2022\/08\/image-236.png 1042w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u56fe\u793a\uff1a\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u7ed3\u5408\u4eb2\u548c\u529b\u4f30\u8ba1\u57fa\u51c6\u7ed3\u679c\u3002\uff08\u6765\u6e90\uff1a\u8bba\u6587\uff09\u7814\u7a76\u4eba\u5458\u76f8\u4fe1\u86cb\u767d\u8d28\u8868\u793a\u5b66\u4e60\u65b9\u6cd5\u5c06\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u5bf9\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u5404\u4e2a\u9886\u57df\u4ea7\u751f\u5f71\u54cd\uff0c\u5e76\u5728\u73b0\u5b9e\u4e16\u754c\u4e2d\u5e94\u7528\uff0c\u8fd9\u8981\u5f52\u529f\u4e8e\u5b83\u4eec\u5728\u8f93\u5165\u7ea7\u522b\u96c6\u6210\u5f02\u6784\u86cb\u767d\u8d28\u6570\u636e\uff08\u5373\u7406\u5316\u6027\u8d28\/\u5c5e\u6027\u3001\u529f\u80fd\u6ce8\u91ca\u7b49\uff09\u7684\u7075\u6d3b\u6027\uff0c\u4ee5\u53ca\u5b83\u4eec\u6709\u6548\u63d0\u53d6\u590d\u6742\u6f5c\u5728\u7279\u5f81\u7684\u80fd\u529b\u3002\u8bba\u6587\u94fe\u63a5\uff1a<em>https:\/\/www.nature.com\/articles\/s42256-022-00457-9<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4ee5\u6570\u636e\u4e3a\u4e2d\u5fc3\u7684\u65b9\u6cd5\u5df2\u88ab\u7528\u4e8e\u5f00\u53d1\u7528\u4e8e\u9610\u660e\u86cb\u767d\u8d28\u672a\u8868\u5f81\u7279\u6027\u7684\u9884\u6d4b\u65b9\u6cd5\uff1b\u7136\u800c\uff0c\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u5e94\u8fdb\u4e00\u6b65\u6539\u8fdb\uff0c\u4ee5\u6709\u6548 &hellip; <a href=\"http:\/\/139.9.1.231\/index.php\/2022\/08\/21\/properties-of-proteins\/\" class=\"more-link\">\u7ee7\u7eed\u9605\u8bfb<span class=\"screen-reader-text\">\u7528\u8bed\u8a00\u6a21\u578b\u5b66\u4e60\u8868\u793a\u86cb\u767d\u8d28\u7684\u529f\u80fd\u7279\u6027<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"_links":{"self":[{"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/posts\/5940"}],"collection":[{"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/comments?post=5940"}],"version-history":[{"count":1,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/posts\/5940\/revisions"}],"predecessor-version":[{"id":5947,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/posts\/5940\/revisions\/5947"}],"wp:attachment":[{"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/media?parent=5940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/categories?post=5940"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/139.9.1.231\/index.php\/wp-json\/wp\/v2\/tags?post=5940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}